Drugs: Prescribed medications can help treat chronic pain as long as the formulation is easy to administer and well-accepted by the cat. NSAIDs (non-steroidal anti-inflammatory drugs) have been mainly used for drug therapy in osteoarthritis. Metacam is a commonly used NSAID for cats but requires a presciption from your vet. The danger to using NSAIDs on cats is their susceptibility to toxicosis, particularly in long term dosing. Most NSAIDs have a long half-life in cats and continued dosing may need to be closely monitored to avoid toxicosis.