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Advantage II Large Dogs 21-55 lbs.|Vet-Recommended Flea Treatment & Prevention|12-Month Supply

Availability: In Stock

Was: $153.99$118.00You Save: $35.99!(23%)


Deliver total flea protection to your dog or puppy with Advantage II Large Dog. This vet-recommended, topical treatment and prevention formula kills adult fleas, flea larvae, and flea eggs on contact within 12 hours of application - meaning fleas can be eliminated before they bite or lay new eggs. Effectively break the flea life cycle, control existing flea and lice infestations, and prevent further infestations with one simple application. Advantage II Large Dog flea and lice protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh 21-55 lbs. to use Advantage II Large Dog.

Advantage II Large Dog is a trademark of Elanco or its affiliates.

Key Benefits:

  • Vet recommended flea treatment and prevention for dogs at weighing 21 to 55 lbs., at least 7 weeks of age
  • Kills adult fleas, flea larvae and flea eggs for total flea prevention and treatment
  • Same-day effectiveness, kills fleas within 12 hours of application and keeps working for 30 days
  • Easy-to-apply topical treatment, no prescription needed
  • Fragrance-free formula, waterproof after 24 hours


Active Ingredients by Weight
Imidacloprid 9.10%
Pyriproxyfen 0.46%
Other Ingredients 90.44%
Total 100.00%

Useful Information

Advantage II Flea Control for Dogs

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

    How To Open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

    How to Apply

  • Remove one applicator tube from the package. See "HOW TO OPEN" section
  • Hold application tube in an upright position facing away from you and your pet's face and eyes. Pull cap of tube.

  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • The dog should be standing for easy application. Part the hair on the dog's back, between the shoulder blades, until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. Do not get this product in your pet's eyes or mouth.

  • Discard empty tube as described in Storage and Disposal.
  • Under normal conditions this product is effective for a month. However, in cases of severe flea infestation, re-treatment may be necessary earlier than four (4) weeks. Do not retreat more often than once every seven (7) days. After flea control is obtained, return to a monthly re-treatment schedule.


  • Use only on dogs. Do not use on other animals.
  • Do not apply more than one (1) tube per treatment, even for larger dogs.
  • Do not have contact or allow children to have contact with treated area until completely dry.

CAUTIONS: Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes or clothing. Wash hands thoroughly with soap and warm water handling. Keep out of reach of children. Do not contaminate feed or food.


For external use only. Do not use on puppies under seven weeks of age. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing animals. Individual sensitivities, while rare, may occur after using ANY pesticide products for pets. If signs persist, or become more severe, consult a veterinarian immediately. If your animal is on medication, consult your veterinarian before using this or any other product.

Customer Reviews

Review Summary
2 Reviews
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100% Recommend this product (2 of 2 responses)
By Olli W.
Excellent for my husky
June 25, 2016
It did what Sentry Fiproguard Plus couldn't do. It got rid of ALL of the fleas on my critter pretty much overnight. I didn't really have any problems with them anywhere except on the husky specifically, but I still combined the application of this with as thorough of a mass cleaning of my apartment as possible. I am not downing Sentry Fiproguard Plus though, but I know fleas get used to that. It worked wonders on another husky I had applied that to last year. Not all products work for every critter and sometimes critters are allergic to certain things in a product that others are not. If one of the good Fipronyl products doesn't work, I'd certainly suggest to try this next considering my success and I had no side effects happen either. Always make sure to read the size/weight of dog any particular product is geared for also. If you have a 25lb dog, don't use a product that is meant for a 75lb dog.
It bloody worked and did exactly what it said it would! WIth my own personal husky, I had no issues with the product at all...only praise o.o
By maryann
Fast shipping
April 3, 2016
quick ship

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