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Advantage II Large Cats Over 9 lbs.|Vet-Recommended Flea Treatment & Prevention|4-Month Supply
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Advantage II Large Cats Over 9 lbs.|Vet-Recommended Flea Treatment & Prevention|4-Month Supply

Item: 5461685
Availability: In Stock
Was: $67.99$51.98You Save: $16.01!(24%)


Deliver total flea protection to your cat or kitten with Advantage II Large Cat. This vet-recommended, topical treatment and prevention formula kills adult fleas, flea larvae, and flea eggs on contact within 12 hours of application - meaning fleas can be eliminated before they bite or lay new eggs. Effectively break the flea life cycle, control existing flea and lice infestations, and prevent further infestations with one simple application. Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.

Advantage II Large Cat is a trademark of Elanco or its affiliates.

Key Benefits:

  • Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application


Active Ingredients by Weight
Imidacloprid 9.10%
Pyriproxyfen 0.46%
Other Ingredients 90.44%
Total 100.00%

Useful Information

View Advantage II for Cats product label.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

How To Open

  1. Be sure tube is at bottom of pouch.
  2. Using scissors, cut the pouch across the top and remove tube.

How to Apply

  1. Remove one applicator tube from the package. See "How to Open" section
  2. Hold application tibe in an upright position facing away from you and your pet's face and eyes. Pull cap of tube.
  3. Turn the cap around and place other end of cap back on tube.
  4. Twist cap to break seal, then remove cap from tube.
  5. Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. Do not get this product in your cat’s eyes, or allow your cat to ingest this product. The product is bitter tasting and salivation may occur for a short time if the cat licks the product immediately after treatment. Treatment at the base of the skull will minimize the opportunity for the cat to lick the product. Do not allow the product to run off.
  6. Discard empty tube as described in Storage and Disposal.
  7. Under normal conditions this product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than four (4) weeks. Do not retreat more often than once every fourteen (14) days for kittens or once every seven (7) days for small and large cats. After flea control is attained, return to a monthly retreatment schedule.


  • Use only on cats or kittens 8 weeks and older. Do not apply to cats or kittens weighing less than 9 lbs. Do not use on other animals.
  • Do not apply more than one (1) tube per treatment, even for larger cats.
  • Do not have contact or allow children to have contact with treated area until completely dry.

Storage and Disposal

Do not contaminate water, food, or feed by storage or disposal.

Pesticide Storage:

Store in a cool, dry place inaccessible to children and pets.

Pesticide Disposal and Container Handling:

Nonrefillable container.

If empty:

Do not reuse this container. place in trash or offer for recycling if available.

If partly filled:

Call your local solid waste agency or 18004229874 for disposal instructions. Never place unused product down and indoor or outdoor drain.


Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes or clothing. Wash hands thoroughly with soap and warm water handling. Keep out of reach of children. Do not contaminate feed or food.

Hazards to Domestic Animals

For external use only.Do not apply to cats or kittens 8 weeks of age or weighing less than 9 lbs. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing cats. Individual sensitivities, while rare, may occur after using ANY pesticide product for cats. If signs persist, or become more severe, consult a veterinarian immediately. If your cat is on medication, consult your veterinarian before using this or any other product.

Possible Side Effects

Monitor your cat after application. Side effects, although very rare, may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Gastrointestinal signs such as hypersalivation, vomiting or diarrhea have also been reported. If these or other side effects (such as lethargy) occur, consult your veterinarian or call 1-800-422-9874.

Customer Reviews

Review Summary
22 Reviews
77% (17)
5% (1)
0% (0)
5% (1)
14% (3)
77% Recommend this product (17 of 22 responses)
By Navid
Used it for almost a year for my car with no issue.
July 29, 2020
Used it for almost a year for my car with no issue. I got good discount on with free delivery and reasonable delivery time.
By rmlb
Use with Caution
August 10, 2018
I purchased the Advantage II for my two indoor cats after using Frontline for many years because I thought it might be a better choice. A day after applying it on both my cats my female vomited a few times during the night and by the next day her eyes were swollen and red and her ears were bright crimson red. I immediately took her to the vet. He gave her a cortisone shot and cortisone medication to take for a week. He felt she might have ingested it somehow. The next morning she was notably better. I can not recommend this product after this experience nor will I be purchasing it again.
Rmlb, we are sorry to hear about the negitive reactoin your indoor cats had to Advantage II. We are glad to hear that they are doing better. It might be possible that your indoor cats might not need a flea medication. Either way, Take care.
By Gina
Houston, TX
My cats hate the goop but I love it.
May 31, 2018
I trust Advantage II for my indoor-only cats. I have to sneak up on them to put it on their necks since cats are not cooperative creatures.
Merchant Response:Great to hear that your taking care of your cat even if it means out smarting them. I'm sure that your cats are secretly thanking you for it and loving you.
By Debbie
Dickson, TN
Excellent Flea Control
February 5, 2018
This is the best flea control I have used. I have medium sized cats but I buy large cat to get more flea control. The cats can go at least 8 weeks with no problem of fleas. I have used this brand for several years.
By Donna
Elberta, Alabama
Works great for fleas!
April 15, 2017
We have used this on 3 cats and it works.
By Sharon
Powder Springs, ga
Advantage II Flea Control
April 6, 2017
My kitties have no signs of fleas so the product must work. I am pleased with the service your company provides.
Merchant Response:No fleas is bliss! Glad they are flea free kitties!
By Estherv
Miami, Florida
Simply and Secure
July 22, 2016
This product is the best formula for cats, clean, quickly. effective and super secure, because is no danger at all for them,
even skin problems, bread problems or poison problems., We use this product for many years with the same result, no
fleas in a record time., thank you!
Super effective Expensive but really good
By Donna
Elberta, Alabama
Works great!
July 19, 2016
We had tried a cheaper product but it was not effective. This product is. No more scratching and No Fleas.
By Gary
Princeton BC
Great Product for Cats
July 9, 2016
it works as advertised easy to administer a great product
By Ellen C.
Montreal, QC
Been Using this Product for Years
May 30, 2016
Works like a charm. No problems with fleas at all.
By Barbara
Gainesville Fl
Not as good as it used to be.
April 4, 2016
My cats still have fleas and I noticed some in the rug.
By Gary
Princeton BC
Great Product for Cats
March 19, 2016
We have used this product on our cats for the past 8 years it works as advertised no side effects highly recommend
pricey but it works as advertised
By C A.
February 29, 2016
This package arrived in a timely manner, and was exactly what I thought I was buying. A good shopping experience.
By Kathy
fayetteville, NC 28303
Not working too well
November 11, 2015
I have used Frontline and Advantage flea control many times before. This order, however, does not seem to be working. I put it on both cats (one large, one small). I combed for fleas before applying. I went about two days and saw a reduction of fleas. Now I am back to combing fleas every day. What is the shelf life of the packages you send out?
By margery
good product
November 11, 2015
very effective
By margery
good product
November 11, 2015
I think this product is very effective
By Grace
Pittsburgh , PA
Trusted this site for many years
September 13, 2015
Always delivers as promised , on time and no shananigans ,ever .
Get what I need when I need it , easy to find produts I'm looking for and orders sent out ASAP . none
By W
Dallas, TX
Effective Flea Control - Long Time User
August 2, 2015
We have been using Advantage for our cats for many years. Fleas are not present on our pets even though they roam occasionally in the back yard. It is my understanding that counterfeit products are often sold online. Healthy Pets provides genuine Bayer products at a good price. Shipping is always prompt and fast.
Ontario, Canada
Best on the Market
July 22, 2015
I've been using this product for my two cats for a number of years. It really does work. No mess, no fuss.
By kittypause
Pittsburgh, Pa
Does its job
April 15, 2015
This is the only brand flea meds that really works for my cats. I'm happy to have found it on sale at such a reasonable price from this website.
By jose
is verry expence
May 10, 2014
is a lot money to buy this product
By Ken
Kills fleas pronto!
September 22, 2012
This costs more and its worth it. Did your pet get out, unexpectedly? Advantage kills fleas within an hour and keeps working for a month or more. No need to repeat monthly if pets have a fles-free indoor life. Use a carpet flea spray to destroy fleas and eggs in carpet and pet bedding. Follow label directions.

Customer Q&A