Vanguard DAP/VanGuard DA2P 25 x 1
formerly known as Vanguard DA2P now will be labeled as Vanguard DAP.
Pfizer Animal Health
Canine Distemper-Adenovirus Type 2-Parainfluenza Vaccine
Modified Live Virus
For use in dogs onlyPRODUCT DESCRIPTION:
Vanguard DAP is for vaccination of healthy dogs as an aid in preventing canine distemper caused by canine distemper (CD) virus infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1) respiratory disease caused by canine adenovirus type 2 (CAV-2) and canine parainfluenza caused by canine parainfluenza (CPI) virus. Vanguard DA2P contains attenuated strains of CD virus CAV-2 and CPI virus propagated on an established canine cell line and freeze-dried to preserve stability.SAFETY AND EFFICACY:
Safety of Vanguard DAP was confirmed in laboratory and field tests.1 In more than 15 000 vaccinated dogs no significant postvaccination reactions attributable to the vaccine were reported. These findings are particularly important since adverse side effects sometimes follow vaccination with modified live ICH vaccine. After vaccination with ICH vaccine persistent kidney infections may occur causing virus shedding in urine. Uveitis and corneal opacity also are occasionally observed 1-2 weeks after vaccination.2 Vaccination with the CAV-2 fraction in Vanguard DAP however produced no such lesions. Challenge virus was not recovered from vaccinated dogs and was not isolated from tissues taken at necropsy. Ocular lesions were not observed in any of 172 dogs inoculated intravenously with multiple doses of CAV-2 vaccine virus while intravenous inoculation of 32 dogs with ICH vaccine produced ocular lesions in 22%. Additionally the strain of CAV-2 in this product has been shown free of oncogenic properties characteristic of canine adenovirus.
Efficacy of Vanguard DAP was demonstrated in challenge-of-immunity studies.1 Dogs vaccinated with the CAV-2 vaccine were completely protected against challenge with virulent ICH virus that produced clinical disease in 100% of nonvaccinated control dogs. Vaccinates were also protected against challenge with virulent CAV-2 that caused severe respiratory syndromes in susceptible controls. After challenge with virulent CD virus 95% of dogs vaccinated with the CD vaccine remained healthy. In contrast all nonvaccinated control dogs developed clinical signs of CD and 80% died. After challenge with virulent CPI virus no clinical signs of disease were observed among dogs vaccinated with CPI vaccine while all nonvaccinated controls revealed clinical signs and severe lung lesions typical of CPI.
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